VT-346 is a 43 kDa secreted glycoprotein that is a novel and potent inhibitor of TNF. The compound has demonstrated an extremely high affinity for human TNF. Additional studies in vitro have shown remarkable potency when compared to other anti-TNF molecules.  Of particular interest are human whole blood experiments, in which cells are stimulated and TNF levels are determined (Figure 1). VT-346 demonstrates greater suppression (10-100 times) of inflammatory responses when compared to the market leading anti-TNFs in this setting.  In addition, several studies examining mechanism of action have also yielded interesting results that are available under a confidentiality agreement with interested parties.